0343 Actigraphy-derived Behavioral Activity Rhythm In Individuals With Insomnia. (27th April 2018)

• Record Type: Journal Article
• Authors: Chen, I Y; Neikrug, A B; Mander, B A; Lamy, M; Benca, R; Morin, C M
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A132
• Page End: A132
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.342
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Activity, as recorded by actigraphy, can be used to extrapolate objective measures of sleep and behavioral sleep/wake rhythmicity. While actigraphy has been widely used in insomnia research, knowledge regarding circadian abnormalities as measured by activity variability across the 24-hour period in individuals with insomnia remains limited. The present study aimed to examine behavioral activity rhythm in insomnia using hour-by-hour aggregation approach. Methods: Seventeen participants with insomnia (INS; 24.94 ± 5.44 years, 64.7% female) and 44 age- and sex-matched good sleepers (GS; 25.23 ± 4.85 years, 70.5% female) participated. Wrist actigraphy recorded daily activity levels in 30-s epochs over a two-week period. Epoch-by-epoch activity counts were aggregated into hour-by-hour bins, and hourly mean activity levels were calculated. Factorial (group x time) mixed models were conducted to examine whether behavioral activity rhythms differed between the INS and the GS participants over the 24-hour period. Results: No significant between-group differences were observed for mean activity throughout the day (INS: 171.28 ± 66.77, GS: 147.65 ± 31.47, p = .169). Mixed models assessing hour-by-hour daily activity revealed a significant group x time interaction (p = .017) with a significant main effect of time (p < .001). The INS group showed significantly lower activity from 7 to 9 PM (all ps < .05). Conclusion: Individuals with insomnia showed reduced diurnal activity, particularly during late evening. This activity difference was only detected when evaluating diurnal pattern of activity as average daytime activity did not differ significantly between groups. A more sedentary behavioral pattern associated with insomnia may have significant clinical implications. Future studies are warranted to evaluate the combined impact of interventions targeting activity rhythm and sleep to improve symptoms in patients. Support (If Any): Research supported by the Canadian Institutes of Health Research (MOP42504).