0461 Polysomnographic And Clinical Differences Between Sleep Apnea Patients With High And Low Sleepiness Response. (27th April 2018)

• Record Type: Journal Article
• Authors: Moraes, W; Prado, L; Prado, G
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A174
• Page End: A174
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.460
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Sleepiness response is the amount of chronic daytime sleepiness associated to the severity of sleep apnea. In order to measure sleepiness response we used a ratio between Epworth Sleepiness Scale scores and apnea/hypopnea index (AHI). The objective of this study is to determine clinical and polysomnographic differences between patients with high and low sleepiness response. Methods: Patients were submitted to full-night polysomnography and clinical interview. Forty-eight patients, 27 females and 21 males, aging 22–79 years with AHI≥5 were included. A ratio between Epworth Sleepiness Scale score and apnea/hypopnea index (E/A ratio) was calculated for each patient in order to assess the sleepiness response to the respiratory disturbance. The sample was divided in two E/A ratio groups: Lower E/A ratio group, below 50 th percentile (<0.32) and higher E/A ratio group, above 50 th percentile (≥0, 32). Differences between both groups were assessed by t-tests for independent samples. Results: The lower E/A ratio group presented shorter slow-wave sleep duration (p<0.05) and lower slow-wave sleep percentage (p<0.01). Patients in the lower E/A ratio group were older (p<0, 05) and had higher AHI (p<0.01). Conclusion: Lower sleepiness response was associated to older age and shorter slow-wave sleep duration. Lower sleepiness response may be associated to a decreased homeostatic process in older patients with sleep apnea syndrome. Support (If Any): FAPESP.