0611 Incidence And Prevalence Of Narcolepsy In A U.S. Healthcare Claims Database, 2008–2010. (27th April 2018)

• Record Type: Journal Article
• Authors: Scheer, D; Schwartz, S; Parr, M; Zgibor, J; Rajaram, L
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A226
• Page End: A227
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.610
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Studies worldwide have reported prevalence estimates (approximately 20–55/100, 000 persons, some specific countries much lower or greater) for narcolepsy. However, epidemiology studies have been limited in the United States, using various methods and data sources, and are subject to biases (e.g. non-response and selection biases). Fewer studies have reported incidence (rate of newly occurring cases) of narcolepsy, with wide ranging estimates and sample sizes. Methods: We used Truven Health MarketScan Commercial Dissertation Database (THMCDD) to estimate incidence and prevalence of narcolepsy (ICD-9-CM = 347.0, 347.00, 347.01, 347.1, 347.10, 347.11) by age groups and gender in those patients continuously enrolled for years 2008–2010. THMCDD encompasses approximately 100 private-sector health insurers covering over 18 million people. Prevalence was estimated by dividing the number of patients with a narcolepsy diagnosis during 2008–2010 by the number of period enrollees. Incident cases were determined by presence of Multiple Sleep Latency Test (MSLT) within 180 days of the first recorded narcolepsy diagnosis. Results: During the period, there were 8, 444, 517 continuously enrolled patients and 6, 703 with a diagnosis of narcolepsy (overall prevalence estimate - 79.4/100, 000). Prevalence (per 100, 000) by age group and gender was: 0–10 years (male:6.1, female:5.0), 11–20 years (male:50.5, female:61.8), 21–30 years (male:97.7, female:154.9), 31–40 years (male:95.0, female:132.0), 41–50 (male:76.7, female:112.1), and 51–65 years (male:75.4, female:93.7). Overall incidence was 9.9/100, 000 persons per year. Incidence (per 100, 000 per year) by age group and gender was: 0–10 years (male:0.6, female:0.4), 11–20 years (male:8.8, female:11.0), 21–30 years (male:14.4, female:22.1), 31–40 years (male:11.1, female:17.9), 41–50 (male:8.5, female:13.9), and 51–65 years (male:6.5, female:10.7). Conclusion: Prevalence and incidence of narcolepsy was greater for females, compared to males, and highest in persons 21–30 years of age. Results from this large U.S. healthcare claims database study suggest that the prevalence and incidence of narcolepsy may have been previously underestimated in U.S. based studies. Support (If Any): None.