0212 Physiological Sleepiness at Baseline Associates with Differential Vulnerability to the Effects of Sleep Loss on Vigilant Attention. (27th April 2018)

• Record Type: Journal Article
• Authors: Tkachenko, O; Dinges, D F
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A83
• Page End: A83
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.211
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: We investigated whether phenotypic differences in neurobehavioral response to chronic partial sleep restriction were associated with baseline sleep propensity. Methods: N=306 healthy adults were randomized to 5 consecutive days of sleep restriction (n=278; 4h TIB, SR1-SR5) or to a control condition (n=28; 10h TIB) after 2 baseline nights in the laboratory (B1-2; 10h TIB). SR subjects in the top and bottom tertiles of change in PVT Lapses from B2 to SR5 were classified as Resilient (n=93) and Vulnerable (n=93), respectively. Groups did not differ in gender, age, or ethnicity (all p >0.10). The Maintenance of Wakefulness Test (MWT) was administered between 1400h-1600h on days B2 and SR5 in N=162 participants (n=19 Controls, n=65 Vulnerable, n=78 Resilient). Subjects were asked to remain awake as long as possible under soporific conditions (max 30min). Wakefulness was monitored with EEG, EMG, and EOG. Latency to Stage 1 sleep was the primary outcome measure. One-Way ANOVAs and Post-hoc t-tests with Bonferroni correction compare MWT data among the three groups. Results: Sleep onset latency varied significantly among the three groups ( F =8.03, p <0.001). Post-hoc tests yielded no significant differences in baseline sleep propensity between Controls and Vulnerable, or Resilient subjects. Vulnerable participants had a significantly shorter latency at baseline (mean=16.7min) as compared with Resilient subjects (mean=22.9min) ( p =0.0002). At SR5, both SR groups had reduced latencies as compared with Controls ( F =7.88, p <0.001). Vulnerable participants again had shorter latency (mean=9.5min) as compared with Resilient subjects (mean=15.6min). Change in sleep onset latency from B2 to SR5 did not differ between Vulnerable and Resilient individuals ( F = 0.88, p =0.42). Both SR groups showed reduced latencies as compared with controls in response to sleep restriction. Conclusion: Physiologic sleepiness at baseline is associated with greater vulnerability to the effects of chronic partial sleep restriction on vigilant attention. These data suggest that fundamental differences in the interaction of waking neurobiology and homeostatic sleep pressure underlie phenotypic vulnerability to sleep loss. Support (If Any): NIH R01 NR004281, NIH CTRC UL1TR000003; NSBRI NASA NCC 9–58.