0429 Exercise Test Responses in Adults with Insomnia and Short Sleep Duration Versus Adults with Good Sleep. (27th April 2018)

• Record Type: Journal Article
• Authors: Erwin, J A; Hall, M H; Buysse, D J; Jakicic, J M; Pietrangelo, E K; Kubala, A G; Kline, C E
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A162
• Page End: A163
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.428
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Insomnia with short sleep duration (ISS) has been shown to be associated with elevated cardiovascular disease (CVD) risk. Exercise testing provides predictive information for CVD risk by examining physiological responses during and after exercise. Therefore, we examined exercise test responses among adults with ISS compared to good sleeper controls (GSC). Methods: 24 adults (8 with ISS, 16 good sleeper controls [GSC]) participated. Adults with ISS (35.8 ± 14.8yo, 4% male, 26.5 ± 4.1 BMI) met DSM-5 criteria for insomnia disorder and self-reported < 6 h sleep/night, while GSCs (30 ± 8.7yo, 29% male, 24 ± 4 BMI) were free from sleep complaints and reported > 6 h sleep/night. Participants were otherwise healthy, free from other DSM-5 and sleep disorders and didn't meet recommended physical activity levels for adults. Participants completed a graded submaximal treadmill test, with test termination at 85% of age-predicted maximal heart rate followed by a standardized active recovery period. Heart rate (HR) and oxygen consumption (VO2) were objectively monitored throughout the test. Cardiorespiratory fitness was assessed by VO2 at the point of test termination. Heart rate recovery (HRR) was calculated as the difference between HR at the time of test termination and 1 min into active recovery. Differences between groups were assessed using one-way ANOVA and effect size calculations (Cohen's d). Results: Cardiorespiratory fitness was moderately, but not significantly, lower among ISS vs. GSC participants (28.6 ± 5.8 vs. 31.1 ± 7.0 ml/kg/min; d=0.39). HR during each of the first 6 minutes of the submaximal test showed small effect sizes (d<0.1) and did not differ between groups. Similarly, HRR did not significantly differ between the ISS and GSC groups (17.0 ± 6.0 vs. 18.2 ± 7.5 beats; d=0.22). Conclusion: These preliminary analyses suggest lower fitness and blunted heart rate recovery among adults with ISS. Effect sizes were small to moderate, but failed to reach statistical significance in this small sample. Although expected considering the relationship between ISS and CVD, these results need to be verified once the full sample (n=50) is obtained and the study is fully powered. Support (If Any): SUPPORT: NIH K23HL118318 (PI: Kline).