0875 Sleep Duration As An Independent Factor Associated With Vitamin D Levels In Episono Cohort. (27th April 2018)

• Record Type: Journal Article
• Authors: de Oliveira, D L; Hirotsu, C; Kim, L J; Tufik, S; Andersen, M L
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A325
• Page End: A325
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.874
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Both obstructive sleep apnea (OSA) and short sleep duration have been separately associated with inadequate levels of 25-hydroxyvitamin D (25OHD). However, whether these 2 factors may concurrently influence 25OHD in the general population is unknown. Thus, we hypothesized that both OSA and short sleep duration would be independently associated with lower concentrations of 25OHD in a gender-dependent manner. Methods: This cross-sectional study is part of the prospective EPISONO cohort (Brazil), which included 712 individuals who underwent polysomnography, answered sleep questionnaires and had their blood collected for serum 25OHD quantification. Results: Individuals with a sleep duration of <6 hours had a 2-fold increased odds of 25OHD<20 ng/mL (OR=2.06, 95% CI 1.04–4.09, p=0.03) compared to those who reported 6 or more hours of sleep, even adjusting for confounding factors. Subset gender analysis revealed that men with a sleep duration of <6 hours had a 4-fold increased odds of 25OHD<20 ng/mL (OR=4.10, 95% CI 1.37–12.23, p=0.01). However, in women, short sleep duration was not associated with lower 25OHD levels. OSA was not an independent factor related to 25OHD concentrations in men or women. Sleep parameters, such as sleep latency, sleep efficiency, arousal index, oxygen saturation and desaturations did not present any association with 25OHD<20 ng/mL. Conclusion: Our findings showed that a sleep duration of <6 hours, but not OSA, was an independent factor associated with 25OHD serum levels below 20 ng/mL, especially in men. Support (If Any): Our study has been supported by grants from the Associação Fundo de Incentivo à Pesquisa (AFIP) and São Paulo Research Foundation (FAPESP, #2014/15259-2 to CH, #2015/19136-5 to LJK, #2016/02205-7 to DLO). MLA is a CNPq fellowship recipient.