0816 The Association Between Vitamin D Status, Limb Movements, And Sleep Architecture. (27th April 2018) - Ingram, D
Abstract: Introduction: Vitamin D deficiency has recently been posited as an important factor in the pathogenesis of restless leg syndrome. We evaluated the association between vitamin D deficiency and limb movements and sleep architecture in a pediatric sample. Methods: This is a retrospective analysis of a single institution sleep program looking at all patients who underwent overnight polysomnogram and 25-OH vitamin D within 60 days of doing the sleep study between January 2015 and October 2017. Those with sleep apnea (Central Apnea Index >5/hr or Obstructive Apnea Hypopnea Index >2/hr) were excluded. Results: There were a total of 83 children who qualified for inclusion. Mean age was 7.0 years (range 1–17 years). Overall, higher Vitamin D level was significantly associated with increasing N3 sleep (r=0.267, p=0.015), but was not significantly associated with other sleep parameters including limb movements. In multivariate regression modelling including Vitamin D and age, the association between vitamin D and N3 sleep percentage remained significant (B=0.212, SE=0.102, p=0.04). Conclusion: Overall, there is a weak positive correlation between vitamin D and N3 sleep, even independent of age. In contrast, there was no association between any limb movement parameter and Vitamin D status. Further investigation is needed to better define the role of Vitamin D in sleep physiology. Support (If Any): NA