0819 A Full Sleep Assessment In Children With Attention Deficit Hyperactivity Disorders (ADHD). (27th April 2018)

• Record Type: Journal Article
• Authors: Miano, S; Ninfa, A; Casadei, A; Manconi, M
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A304
• Page End: A304
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.818
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: One of the most extensively researched areas concerns sleep disorders associated with ADHD. Based on sleep information, the main aim of our study was to classify children with ADHD in one of the following 5 phenotypes:1) narcolepsy-like; 2) sleep onset insomnia; 3) obstructive sleep apnea syndrome; 4) sleep hyperkinesia, and/or periodic limb movements; and 5) sleep epilepsy and/or EEG interictal epileptiform discharges. Secondary aim was to explore differences ADHD patients and controls in the slow wave activity (SWA) scalp distribution and source by using high density EEG (HD-EEG). Methods: A case-control sleep study in children with ADHD was carried out. Children with ADHD (mean age 10.1 ± 2.1 years), underwent a battery of sleep questionnaires, a video-PSG-HD-EEG (256 channels), MSLT, and 1-week actigraphy. SWA topography and source during the first cycle of NREM sleep were analysed in both groups. Results: 30 patients and 30 controls were recruited. The narcoleptic-like phenotype was found in 4 children, a sleep onset insomnia in 5 children, an obstructive sleep apnea in 7 children, a sleep hyperkinesia and/or periodic limb movements in 8 children, while an EEG interictal epileptiform discharges and/or nocturnal epilepsy in 5 subjects. All patients had a mean total sleep time < 9 hours at actigrapy. ADHD patients slept less and had a higher AHI than controls measured by PSG. At scalp topography, both groups showed a similar distribution of SWA, but with a group specific activity pattern. In ADHD subjects, the focus of slow wave activity was observed over centro-parietal regions, whereas in controls it was prominent over frontal regions. The statistical non parametric comparison of localized sources showed a significantly greater delta power over the posterior cingulates in ADHD group compared to controls. Conclusion: The study confirms the relevant association between ADHD and defined sleep disorders, inducing a chronic sleep deprivation. The HD-EEG mapping and source analysis confirms a maturation delay of SWA, which may also reflect a state of sleep deprivation. Support (If Any): ABREOC.