535PLower tumor mutational burden (TMB) and hepatic metastases may predict for lack of response to PD-1 blockade in MSI-H metastatic colorectal cancer (MCRC). (23rd October 2018) - Amanam, I; Chao, J; Lim, D; Rahmanuddin, S; Schrock, A B; Ali, S M; Lau, C; Chevalier, D; Harris, E; Saluja, J; Wang, C; Fakih, M