Evaluation of the Presence of Deletion of the Long Arm of Chromosome 20 in Multiple Myeloma. (21st September 2018)

• Record Type: Journal Article
• Authors: Van Rheeden, Richard; Koslosky, Lori; Dunham, Timothy
• Is Part Of: American journal of clinical pathology. Volume 150(2018)Supplement 1
• Page Start: S114
• Page End: S114
• Publication Date: 2018-09-21
• Subjects: Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqy097.276
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To determine the occurrence of deletion of the long arm of chromosome 20 in cytogenetic studies of multiple myeloma patients. Methods: A retrospective study of cytogenetic studies from patients with a diagnosis of multiple myeloma was undertaken to determine the most common cytogenetic abnormalities identified. A total of 456 patients with at least four cytogenetic studies from the past 10 years were reviewed. Results: Of these patients, 135 (29.6%) exhibited abnormal chromosomes within the period of the review. Of the abnormal results, 33 (24.4%) had an abnormality involving one chromosome, and 101 (74.4%) had abnormalities involving more than one chromosome. One abnormal result was determined to be constitutional (.8%) of the abnormal and 0.22% of the total patients. The most common single-chromosome abnormality was a deletion of the long arm of chromosome 20. A total of 17 of the 33 patients (51.5%) exhibited this abnormality. The next most numerous of this type of abnormality included four (12.1%) patients with a deletion of the long arm of 13. Two (6%) patients had a deletion of the long arm of chromosome 5. Conclusion: Further investigation is required to determine if these deletions are related to the initial diagnosis of multiple myeloma or are a secondary treatment-induced myeloid disorder.