Is Human Papillomavirus Infection Among HIV-Infected Men in Kenya Underestimated?. (21st September 2018)

• Record Type: Journal Article
• Authors: Mokua, Grace; Rogena, Emily; Kigondu, Christine; Rioki, Josephine; Ngayo, Musa Otieno
• Is Part Of: American journal of clinical pathology. Volume 150(2018)Supplement 1
• Page Start: S81
• Page End: S81
• Publication Date: 2018-09-21
• Subjects: Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqy094.197
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To detect the prevalence of HPV infection in urine samples among HIV-infected men attending CCC in a high-volume hospital in Kenya and to determine performance of molecular diagnosis against cytological evaluation in urine samples for the diagnosis of HPV infection among HIV-infected men attending CCC in a high-volume hospital in Kenya. Methods: Real-time PCR and cytomorphological evaluation. Results: HPV oncogenic types with real-time PCR = 25.3% and cytomorphological changes = 8.4%. The agreement of RT-PCR with cytology was fair (κ, 0.264). The carcinogenic HPV detection for PCR as reference, concordance, sensitivity, and specificity for cytology was 91.6%, 23.9%, and 96.8%, respectively. Conclusion: Prevalence of oncogenic HPV infection was high among HIV men; also, there was an increase in cytological grading, supporting the validity of urine sampling for evaluation.