BCNTB bioinformatics: the next evolutionary step in the bioinformatics of breast cancer tissue banking. Issue Volume 46:Issue D1(2018) (9th October 2017)

• Record Type: Journal Article
• Authors: Gadaleta, Emanuela; Pirrò, Stefano; Dayem Ullah, Abu Zafer; Marzec, Jacek; Chelala, Claude
• Is Part Of: Nucleic acids research. Volume 46:Issue D1(2018)
• Page Start: D1055
• Page End: D1061
• Publication Date: 2017-10-09
• Subjects: Nucleic acids -- Periodicals; Molecular biology -- Periodicals; 572.805
• DOI: 10.1093/nar/gkx913
• Languages: English
• ISSNs: 0305-1048

Abstract

Abstract: Here, we present an update of Breast Cancer Now Tissue Bank bioinformatics, a rich platform for the sharing, mining, integration and analysis of breast cancer data. Its modalities provide researchers with access to a centralised information gateway from which they can access a network of bioinformatic resources to query findings from publicly available, in-house and experimental data generated using samples supplied from the Breast Cancer Now Tissue Bank. This in silico environment aims to help researchers use breast cancer data to their full potential, irrespective of any bioinformatics barriers. For this new release, a complete overhaul of the IT and bioinformatic infrastructure underlying the portal has been conducted and a host of novel analytical modules established. We developed and adopted an automated data selection and prioritisation system, expanded the data content and included tissue and cell line data generated from The Cancer Genome Atlas and the Cancer Cell Line Encyclopedia, designed a host of novel analytical modalities and enhanced the query building process. Furthermore, the results are presented in an interactive format, providing researchers with greater control over the information on which they want to focus. Breast Cancer Now Tissue Bank bioinformatics can be accessed at http://bioinformatics.breastcancertissuebank.org/ .