AntiTbPdb: a knowledgebase of anti-tubercular peptides. (28th February 2018)

• Record Type: Journal Article
• Authors: Usmani, Salman Sadullah; Kumar, Rajesh; Kumar, Vinod; Singh, Sandeep; Raghava, Gajendra P S
• Is Part Of: Database. Volume 2018(2018)
• Publication Date: 2018-02-28
• Subjects: Biology -- Databases -- Periodicals; Bioinformatics -- Periodicals; 570.285
• DOI: 10.1093/database/bay025
• Languages: English
• ISSNs: 1758-0463

Abstract

Abstract: Tuberculosis is a global menace, caused by Mycobacterium tuberculosis, responsible for millions of premature deaths every year. In the era of drug-resistant tuberculosis, peptide-based therapeutics may provide alternate to small molecule based drugs. In order to create knowledgebase, AntiTbPdb (http://webs.iiitd.edu.in/raghava/antitbpdb/ ), experimentally validated anti-tubercular and anti-mycobacterial peptides were compiled from literature. We curate 10 652 research articles and 35 patents to extract anti-tubercular peptides and annotate these peptides manually. This knowledgebase has 1010 entries, each entry provides extensive information about an anti-tubercular peptide such as sequence, chemical modification, chirality, nature and source of origin. The tertiary structure of these anti-tubercular peptides containing natural as well as chemically modified residues was predicted using PEPstrMOD and I-TASSER. In addition to structural information, database maintains other properties of peptides like physiochemical properties. Numerous web-based tools have been integrated for data retrieval, browsing, sequence similarity search and peptide mapping. In order to assist wide range of user, we developed a responsive website suitable for smartphone, tablet and desktop. Database URL : http://webs.iiitd.edu.in/raghava/antitbpdb/