0099 Effects of Sleep Disruption on Reward Learning in Healthy Adults. (27th April 2018)

• Record Type: Journal Article
• Authors: Robinson, M L; Whitton, A E; Remeniuk, B; Smith, M T; Letzen, J E; Irwin, M R; Pizzagalli, D A; Finan, P H
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A40
• Page End: A40
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.098
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Sleep disorders, such as insomnia, increase vulnerability for depression, but the mechanisms underlying this relationship are not well known. We investigated the effects of experimental sleep disruption on reward response bias (RRB), a measure of reward learning linked to mesolimbic reward system function and depression. Methods: Participants (N=39) were healthy good sleeping adults enrolled in a within-subject crossover sleep disruption experiment that incorporated one night of uninterrupted sleep (US) and one night of forced awakenings (FA) in random order. On the day following each experimental sleep night, participants completed a probabilistic reward task to assess RRB, and the Positive and Negative Affect Schedule-X (PANAS-X) to assess state positive affect (PA) and negative affect. Mixed effects models evaluated within-subject differences in RRB. Participants were also subgrouped into Resilient (n=15) and Non-Resilient (n=24) responders to the sleep disruption manipulation based on whether their PA scores were maintained/increased or decreased, respectively, between US and FA conditions. Results: Across participants, RRB did not significantly differ between the US and FA sleep conditions (p = .86). However, the effect of sleep condition on RRB was moderated by positive affect resilience (p = .02). Post-hoc tests indicated that individuals whose PA decreased after FA showed diminished reward learning following FA, whereas individuals whose PA was maintained or increased after FA showed heightened reward learning following FA. Conclusion: The propensity to lose PA through periods of sleep disruption may be a marker of diminished capacity for reward learning. In contrast, the propensity to maintain PA following sleep disruption appears to reflect an upregulation of reward learning. Understanding how sleep disruption impacts PA and reward learning identifies a pathway linking sleep disturbance to depression risk. Support (If Any): K23DA03915 (PHF); R01DA032922 (MTS/MRI).