TLR9 stimulation induces increase in fungicidal activity of human dendritic cells challenged with Paracoccidioides brasiliensis. (8th December 2017)

• Record Type: Journal Article
• Authors: Vieira, Ivy Rafacho; Fernandes, Reginaldo Keller; Rodrigues, Daniela Ramos; Gorgulho, Carolina Mendonça; Kaneno, Ramon; Soares, Ângela Maria Victoriano Campos
• Is Part Of: Medical mycology. Volume 56:Number 7(2018)
• Page Start: 911
• Page End: 915
• Publication Date: 2017-12-08
• Subjects: Paracoccidioides brasiliensis -- dendritic cells -- TLR9 -- fungicidal activity -- H2O2; Medical mycology -- Periodicals; Veterinary mycology -- Periodicals; Mycology -- Periodicals; Mycoses -- Periodicals; Pathogenic fungi -- Periodicals; 616.969005
• DOI: 10.1093/mmy/myx126
• Languages: English
• ISSNs: 1369-3786

Abstract

Abstract: Microorganisms killing by dendritic cells (DCs) is an important effector mechanism during innate immune response, as it can avoid dissemination of infection during migration of these cells toward draining lymph nodes. However, this function depends on pattern recognition receptors (PRRs) to which the microorganism will bind in these cells. Regarding this, TLR9 activation, by stimulating the oxidative metabolism, induces increase in microbicidal activity of these cells. Accordingly, we showed that DCs treatment with a TLR9 agonist results in an increase in fungicidal activity of these cells against the fungus Paracoccidioides brasiliensis (Pb), which however, was not associated to higher H2 O2 levels.