NIMG-75. WHO 2016 GRADE II GLIOMA MOLECULAR SUBTYPES HAVE A DISTINCT SPATIAL DISTRIBUTION PATTERN. (5th November 2018)

• Record Type: Journal Article
• Authors: Wijnenga, Maarten; van der Voort, Sebastian; French, Pim; Klein, Stefan; Dubbink, Hendrikus; Dinjens, Winand; Atmodimedjo, Peggy; Schouten, Joost; Kros, Johan; Dirven, Clemens; Vincent, Arnaud; Smits, Marion; van den Bent, Martin
• Is Part Of: Neuro-oncology. Volume 20(2018)Supplement 6
• Page Start: vi192
• Page End: vi192
• Publication Date: 2018-11-05
• Subjects: Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noy148.797
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: INTRODUCTION: Several studies reported a correlation between the anatomic location of gliomas and the genetic background of the tumor. As such, tumor location may contribute to pre-surgical clinical decision-making. Current evidence is mainly derived from smaller series and report single genes or copy numbers, but not the integrated WHO 2016 classification. Our purpose was to assess the location distribution of different WHO 2016 glioma subgroups in a consecutive series of molecularly defined grade II glioma and to create location heatmaps of the low grade glioma molecular subtypes. METHODS: 205 adult patients with a grade II supratentorial glioma diagnosed between 2003–2016 were included in this study (100 IDH mutated astrocytoma, 85 IDH mutated and 1p19q co-deleted oligodendroglioma, and 20 IDH wildtype astrocytoma). All patients were classified according to the WHO 2016 criteria using a dedicated Next-Generation-Sequencing panel. Tumor volume and location were assessed with semi-automatic software on T2-weighted images. All volumes of interest were mapped to a standard brain using affine registration. Location heatmaps were created for each WHO 2016 glioma subgroup by overlaying segmentations on a standard brain. RESULTS: Our location maps confirmed earlier observations that different molecular subtypes of grade II glioma have a different spatial distribution: most IDH mutated 1p19q co-deleted oligodendrogliomas were located in the frontal lobes and cortex, while IDH mutated astrocytomas were more frequently located in the frontotemporal and insular region. IDH wildtype astrocytomas were predominantly located in the basal ganglia and temporal lobes. Our observations were significant as confirmed with voxel-based Fisher's exact tests (figures will be shown at SNO). CONCLUSION: Each WHO 2016 glioma subgroup displayed a distinct pattern of spatial distribution. Our observations may contribute to pre-surgical clinical decision-making and to radiogenomics.