Identification of multiple species and subpopulations among Australian clinical Sporothrix isolates using whole genome sequencing. (30th November 2018)

• Record Type: Journal Article
• Authors: New, David; Beukers, Alicia G; Kidd, Sarah E; Merritt, Adam J; Weeks, Kerry; van Hal, Sebastiaan J; Arthur, Ian
• Is Part Of: Medical mycology. Volume 57:Number 7(2019)
• Page Start: 905
• Page End: 908
• Publication Date: 2018-11-30
• Subjects: Sporothrix, Australia -- whole genome sequencing -- calmodulin -- phylogeny; Medical mycology -- Periodicals; Veterinary mycology -- Periodicals; Mycology -- Periodicals; Mycoses -- Periodicals; Pathogenic fungi -- Periodicals; 616.969005
• DOI: 10.1093/mmy/myy126
• Languages: English
• ISSNs: 1369-3786

Abstract

Abstract: Whole genome sequencing (WGS) was used to demonstrate the wide genetic variability within Sporothrix schenckii sensu lato and establish that there are two main species of Sporothrix within Australian clinical isolates— S. schenckii sensu stricto and Sporothrix globosa. We also demonstrated southwest Western Australia contained genetically similar S. schenckii ss strains that are distinct from strains isolated in the eastern and northern states of Australia. Some genetic clustering by region was also noted for northern NSW, Queensland, and Northern Territory. Phylogenetic analysis of WGS data provided greater phylogenetic resolution compared to analysis of the calmodulin gene alone.