AllerGAtlas 1.0: a human allergy-related genes database. (22nd February 2018)

• Record Type: Journal Article
• Authors: Liu, Jinying; Liu, Yuan; Wang, Dan; He, Mengqi; Diao, Lihong; Liu, Zhongyang; Li, Yang; Tang, Li; He, Fuchu; Li, Dong; Guo, Shuzhen
• Is Part Of: Database. Volume 2018(2018)
• Publication Date: 2018-02-22
• Subjects: Biology -- Databases -- Periodicals; Bioinformatics -- Periodicals; 570.285
• DOI: 10.1093/database/bay010
• Languages: English
• ISSNs: 1758-0463

Abstract

Abstract: Allergy is a detrimental hypersensitive response to innocuous environmental antigen, which is caused by the effect of interaction between environmental factors and multiple genetic pre-disposition. In the past decades, hundreds of allergy-related genes have been identified to illustrate the epidemiology and pathogenesis of allergic diseases, which are associated with better endophenotype, novel biomarkers, early-life risk factors and individual differences in treatment responses. However, the information of all these allergy-related genes is dispersed in thousands of publications. Here, we present a manually curated human allergy-related gene database of AllerGAtlas, which contained 1195 well-annotated human allergy-related genes, determined by text-mining and manual curation. AllerGAtlas will be a valuable bioinformatics resource to search human allergy-related genes and explore their functions in allergy for experimental research. Database URL : http://biokb.ncpsb.org/AlleRGatlas/