0304 Do Parkinson's Disease Patients with Probable REM Behavior Disorder Report Poorer Sleep Quality than Patients without Probable REM Behavior Disorder?. (12th April 2019)

• Record Type: Journal Article
• Authors: Trout, Jonathan; Christiansen, Taylor; Escobar, Ariel; Bulkley, M Brooks; Tanner, Jared J; Bowers, Dawn; Kay, Daniel B
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A124
• Page End: A124
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.303
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Parkinson's disease (PD) is a multisystem movement disorder often presenting with comorbid sleep difficulties. REM Sleep Behavior Disorder (RBD), characterized by vocalizations or complex behavior and a loss of atonia during REM sleep, often accompanies PD. The purpose of this analysis was to investigate associations between RBD and self-reported sleep features in patients with PD. Methods: Participants included PD patients with probable RBD ( n =19), PD patients without probable RBD ( n =31), and matched controls free of neurodegenerative disease ( n =47). Probable RBD was determined using the REM Sleep Behavior Disorder Screening Questionnaire (total score >6). Subjective total sleep time and sleep onset latency were measured with the Pittsburgh Sleep Quality Index, insomnia severity was assessed using the Insomnia Severity Index, daytime sleepiness was evaluated using the Epworth Sleepiness Scale, and sleep disturbance and sleep-related impairment were assessed using the Patient-Reported Outcomes Measurement Information System questionnaires. Mann-Whitney U tests were used to test for group differences (all PD patients vs. matched controls and PD with probable RBD vs. PD without RBD) in these sleep features. Results: Patients with PD had significantly higher insomnia severity, daytime sleepiness, and sleep-related impairment than matched controls: Z =-2.52, p =0.012, Z =-2.18, p =0.029, Z =-4.48, p <0.001, respectively. No significant differences were found in sleep measures between the PD with probable RBD and the PD without probable RBD groups ( p >0.05). Conclusion: Parkinson's disease is associated with poorer sleep quality. Self-reported sleep problems are not unique to or more severe in PD patients with probable RBD. Given that RBD is associated with poorer daytime impairments on executive tasks, the finding that PD patients with probable RBD report comparable levels of sleep-related impairments as PD patients without RBD may suggest they are unaware of the impact RBD has on their daytime functioning. Support (If Any)