0403 Older Adults with Sleep Onset Insomnia Are More Responsive to Open-Loop Audio-Visual Stimulation Based Delta Induction Than Are Those with Sleep Maintenance Insomnia. (12th April 2019)

• Record Type: Journal Article
• Authors: Tang, Jean; McCurry, Susan M; Riegel, Barbara; Pike, Kenneth C; Vitiello, Michael V
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A163
• Page End: A163
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.402
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Previous findings reported from our pilot RCT treating chronic insomnia in older adults with osteoarthritis demonstrated that 30-minute baseline training of open-loop Audio and Visual Stimulation (AVS) induced significant delta activity relative to an AVS control. Also, active AVS used for two weeks improved sleep in subjects with difficulties with sleep onset (SO) relative to those with sleep maintenance (SM). Here we further explore the hypothesis that subjects with SO difficulties respond differently to active AVS than those with SM difficulties by examining delta induction during baseline active AVS training and changes in the self-reported sleep measures following 2 weeks of AVS. Methods: We studied 16 subjects (active AVS: n=9, mean age 67.2; control AVS: n=7, mean age 69.6) from our RCT for whom baseline QEEG data were available for baseline AVS training. Active AVS provided stimulation declining from 8Hz to 2Hz over 30 minutes, while control AVS idled below 0.5Hz. Subjects received baseline AVS training during which QEEG was recorded and then used AVS at home prior to bedtime nightly for 2 weeks. Self-reported sleep measures (Insomnia Severity Index (ISI), and sleep diary) were collected at baseline and at 2 weeks. Results: Within baseline active AVS subjects, delta induction change in z-score over Cz was greater, albeit non-significantly, for SO (n=3, 2.7±1.04) than SM (n=6, 1.62±0.86). Both SO and SM control AVS subjects demonstrated minimal delta induction. In addition, within active AVS, SO subjects reported significant improvement in self-reported sleep measures (ISI -9.67±4.51, p =.01; sleep diary latency -27± 22.83, p =.01) compared to SM at 2 weeks. No significant sleep changes were reported within control AVS. Conclusion: Sleep onset insomniacs are more responsive to AVS than are sleep maintenance insomniacs and appear to demonstrate differential sensitivity to active AVS even upon first exposure. Support (If Any): Project supported by Research & Intramural Funding Program, School of Nursing, University of Washington