P154 Development of a novel ultrasound based score for assessing disease activity in ulcerative colitis: preliminary results. (25th January 2019)

• Record Type: Journal Article
• Authors: Kakkadasam Ramaswamy, P; Yelsangikar, A; Nagarajan, K V; Nagar, A; Bhat, N
• Is Part Of: Journal of Crohn's and colitis. Volume 13(2019)Supplement 1
• Page Start: S166
• Page End: S166
• Publication Date: 2019-01-25
• Subjects: Inflammatory bowel diseases -- Periodicals; 616.344005
• DOI: 10.1093/ecco-jcc/jjy222.278
• Languages: English
• ISSNs: 1873-9946

Abstract

Abstract: Background: Colonoscopy based scores are the gold standard for assessing disease activity in ulcerative colitis (UC). The aim of this study was to develop a new bowel ultrasound (USG) based score for assessing disease activity in UC and to assess its correlation with Mayo endoscopic score (MES). Methods: Patients who underwent colonoscopy for assessment of disease activity also underwent USG within 2 weeks. Endoscopic activity was graded with MES; clinical disease activity was assessed using the Total Mayo Score (TMS). All assessments were performed for the rectum, sigmoid, descending, transverse, and ascending colon and caecum. A novel score based on Colonic wall thickness (CWT), loss of bowel wall stratification, Doppler activity (D) was calculated for each segment and correlated to the MES. USG based score. Results: A total of 102 colonic segments were analysed. Median CWT was lower in patients with MES 0-1 when compared with MES 2-3 (3 mm vs. 4.1 mm, p = 0.01). The ultrasound score (USS) was calculated for each colonic segment and correlated to the MES for that particular segment. USS correlation to MES for each segment was as follows: caecum ( r = 0.95, p = 0.0001); ascending colon ( r = 0.9, p = 0.001), transverse colon ( r = 0.955, p = 0.0001), descending colon ( r = 0.845, p = 0.001), sigmoid colon ( r = 0.816, p = 0.0001), rectum ( r = 0.761, p = 0.001). The USS for sigmoid colon correlated with the overall MES ( r = 1, p = 0.0001), and Total Mayo Score ( r = 0.918, p = 0.0001). Conclusions: The novel ultrasound score has excellent correlation with MES. USS assessment of the sigmoid colon correlates with overall endoscopic activity and the Total Mayo score.