0977 The Association Between Alcohol Craving And Insomnia Symptoms In Alcohol Dependent Individuals. (27th April 2018)

• Record Type: Journal Article
• Authors: He, S; Kampman, K; Chakravorty, S
• Is Part Of: Sleep. Volume 41(2018)Supplement 1
• Page Start: A362
• Page End: A363
• Publication Date: 2018-04-27
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy061.976
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Insomnia in Alcohol Dependence (AD) is a risk factor for relapse during early recovery whereas increased alcohol craving is a risk factor for drinking and a target for treatment in AD. The direct association between insomnia and alcohol craving in AD is currently unknown. The aim of this preliminary investigation was to evaluate this relationship between alcohol craving and insomnia symptoms in actively drinking patients with AD, after adjusting for covariates. Methods: An analysis of cross-sectional data acquired from baseline assessments in subjects with AD (N=61) who participated in a trial evaluating quetiapine for AD. Subjects were treatment-seeking alcohol-dependent patients who drank heavily but medically and psychiatrically stable. The Penn Alcohol Craving scale (PACS) evaluated their alcohol craving, the validated Short Sleep Index (SSI) evaluated their insomnia symptoms, Addiction Severity Index (ASI) modules evaluated their socio-demographic and global psychiatric characteristics and Time Line Follow Back measures (TLFB) evaluated their alcohol consumption over the last 90 days. Linear regression analyses evaluated the relationship between alcohol craving and insomnia symptoms in crude and adjusted models. Results: The sample was predominantly male (77.0%), White (51.6%), and single (68.8%). Their mean (SD) age was 46.3(10.6) years, education was 13.8(2.6) years and the proportion of days of heavy drinking in the last 90 days were 53.1(46.2)% and their psychiatric scale score on the ASI was 0.1 (0.1). About half the sample reported the presence of insomnia symptoms (49.1%). The mean (SD) for PACS total score was 15.9(8.5) and the SSI score was 2.1(2.3). Alcohol craving was associated with insomnia symptoms in the crude model (β=6, p=0.006) as well as in the model adjusted for covariates (R 2 =0.16, β=4.5, p=0.04). Secondary analysis demonstrated that PACS scores were significantly higher for those reporting difficulty falling asleep (p=0.03). We demonstrated similar trends for restless sleep, sleep maintenance insomnia and early morning awakening, but these relationships did not reach statistical significance. Conclusion: Insomnia was associated with higher alcohol craving. Alcohol craving may lead to alcohol use in those with comorbid AD and insomnia. Support (If Any): IK2CX000855(S.C.).