Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis. Issue 11 (November 2019)

• Record Type: Journal Article
• Authors: Schapowal, Andreas; Dobos, Gustav; Cramer, Holger; Ong, Kian Chung; Adler, Martin; Zimmermann, Andrea; Brandes-Schramm, Juliette; Lehmacher, Walter
• Is Part Of: Heliyon. Volume 5:Issue 11(2019)
• Publication Date: 2019-11
• Subjects: Respiratory system -- Infectious disease -- Pharmacology -- Evidence-based medicine -- Clinical research -- Common cold -- Efficacy -- EPs 7630 -- Meta-analysis -- Pelargonium sidoides -- Safety; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2019.e02904
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: The efficacy of Pelargonium sidoides preparation EPs 7630 in the common cold (CC) was assessed by performing meta-analyses of randomized, double-blind, placebo-controlled trials. Mean differences (MD) and risk ratios (RR) with their 95% confidence intervals (CI) were computed. Five trials with a total of 833 patients were included. All trials had a treatment period of ten days with visits at days 3, 5, and 10 after baseline and used a ten-symptom Cold Intensity Score (CIS) as the primary outcome. Significant differences favoring EPs 7630 were observed for total CIS reduction (day 5: MD = -2·30; 95%CI = -4·12, -0·49; day 10: MD = -1·16; 95%CI = -2·22, -0·10), proportion of patients with substantial improvement (day 5: RR = 1·73; day 10: RR = 1·06) and complete remission (day 5: RR = 2·52; day 10: RR = 2·13). Subjects treated with EPs 7630 missed fewer days at work, used less paracetamol and had an improved sleep quality. No serious adverse reactions to EPs 7630 were reported. The results support the efficacy of EPs 7630 in adults with CC. Abstract : Respiratory system; Infectious disease; Pharmacology; Evidence-based medicine; Clinical research; Common cold, Efficacy, EPs 7630, Meta-analysis, Pelargonium sidoides, Safety