Insight into interleukin-37: The potential therapeutic target in allergic diseases. (October 2019)

• Record Type: Journal Article
• Authors: Huang, Zhaohao; Xie, Lihui; Li, He; Liu, Xiuxing; Bellanti, Joseph A.; Zheng, Song Guo; Su, Wenru
• Is Part Of: Cytokine & growth factor reviews. Volume 49(2019)
• Page Start: 32
• Page End: 41
• Publication Date: 2019-10
• Subjects: AR allergic rhinitis -- AD allergic dermatitis -- IL-37 interleukin-37 -- rIL-37 recombinant interleukin-37 -- IL-37tg interleukin-37 transgenic -- Smad3 mothers against decapentaplegic homolog 3 -- FIL1ξ family of interleukin-1ξ -- IL-1H4 interleukin-1 homologues 4 -- IL-1RP1 interleukin-1-related protein 1 -- IL-1H interleukin-1 homologues -- IL-1F7 interleukin-1 family member 7 -- LPS lipopolysaccharide -- PBMCs peripheral blood mononuclear cells -- DCs dendritic cells -- TLR toll-like receptor -- IFN-γ interferon-γ -- TNF-α tumor necrosis factor α -- RA rheumatoid arthritis -- SLE systemic lupus erythematosus -- IBD inflammatory bowel disease -- TGF-β transforming growth factor beta -- IL-18Rα interleukin-18 receptor α -- IL-1R8 interleukin-1 receptor 8 -- TIR toll/IL-1 receptor -- SIGIRR single Ig IL-1R-related molecule -- IL-18BP interleukin-18 Binding Protein -- ERK extracellular signal-regulated kinase -- p38MAPK p38 mitogen-associated protein kinase -- JNK c-Jun N-terminal kinase -- PI3K phosphatidylinositide 3-kinases -- AKT protein kinase B -- mTOR The mammalian target of rapamycin -- NF-κB nuclear factor kappa-B -- TAK1 transforming growth factor beta-activated kinase -- STAT signal transducers and activators of transcription -- PTEN phosphatase and tensin homolog deleted on chromosome ten -- GM-CSF granulocyte-macrophage colony stimulating factor -- ICAM-1 intercellular cell adhesion molecule-1 -- BMDMs bone marrow-derived macrophages -- HDM house dust mite -- AHR airway hyperreactivity -- TH2 T helper 2 -- OVA ovalbumin -- BALF bronchoalveolar lavage fluid -- ILC innate immune cells -- ASMC airway smooth muscle cells -- TEC tracheobronchial epithelial cells -- AEC alveolar epithelial cells -- TSLP thymic stromal lymphopoietin -- ECP Eosinophil Cationic Protein -- Treg regulatory T cells -- ACD allergic contact dermatitis -- CHS contact hypersensitivity; Allergic diseases -- Anti-inflammatory effect -- Hypersensitivity -- Inflammation -- Interleukin-37; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2019.10.003
• Languages: English
• ISSNs: 1359-6101

Abstract

Graphical abstract: Highlights: IL-37 exhibits protective effect in allergic diseases, such as asthma, allergic rhinitis and allergic dermatitis. IL-37 is a likely target for the treatment of allergic diseases. IL-37 functions extracellular effect by forming a complex with IL-18Rα and relies on Smad3 to exert intracellular effect. IL-37 plays an anti-allergic role by regulating the balance between Th1 and Th2 cells. Abstract: Allergic diseases are ubiquitous diseases with detrimental effects on the quality of life of people worldwide. Common allergic diseases include asthma, allergic rhinitis (AR) and allergic dermatitis (AD). Recently, studies have shown that interleukin (IL)-37, a novel cytokine in the IL-1 family, exhibits broad protective properties in various diseases, such as autoimmune diseases and cancer. IL-37 displays its anti-inflammatory effect on diseases by curbing innate and acquired immunity as well as inflammatory reactions. IL-37 functions by forming a complex with IL-18Rα and IL-1R8 extracellularly and can be translocated to the nucleus upon forming a complex with mothers against decapentaplegic homolog 3 (Smad3) intracellularly, thereby affecting gene transcription and signaling pathway activation. In addition, increasing evidence confirms that IL-37 expression is aberrant in asthma, AR and AD, which indicates that IL-37 may also play essential roles in allergic diseases. Furthermore, accumulating data obtained from recombinant IL-37 (rIL-37)-treated mice and from IL-37 transgenic (IL-37tg) mice suggest a protective role for IL-37. This review will detail the role of IL-37 in the occurrence and development of allergic diseases and discuss the potential of IL-37 as a therapeutic target in allergic diseases.