Management of Barrett's esophagus with low-grade dysplasia. Issue 4 (1st March 2018)

• Record Type: Journal Article
• Authors: Harrison, M; Allen, J E; Gorrepati, V S; López-Jamar, J M E; Sharma, P
• Is Part Of: Diseases of the esophagus. Volume 31:Issue 4(2018)
• Publication Date: 2018-03-01
• Subjects: Barrett's esophagus -- confirmed low-grade dysplasia -- endoscopic treatment for low-grade dysplasia -- esophageal cancer -- persistent low-grade dysplasia -- progression; Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1093/dote/doy004
• Languages: English
• ISSNs: 1120-8694

Abstract

SUMMARY: Barrett's esophagus progresses to esophageal adenocarcinoma in a stepwise histological fashion of no dysplasia, low grade dysplasia, high grade dysplasia and cancer. Hence the progression to cancer from various histological stages is different. Progression to cancer from low grade dysplasia is highly variable in the literature due to high inter-observer variability between pathologists in diagnosing it. Studies have shown the utility of having confirmation of low grade dysplasia by expert pathologists or documenting its persistence on two subsequent endoscopies in order to unify the diagnosis. The treatment of low grade dysplasia is variable. In this article we summarize the diagnosis, evaluation and management of low grade dysplasia in Barrett's Esophagus