Vertebral Compression Fracture After Spine Stereotactic Body Radiation Therapy: A Review of the Pathophysiology and Risk Factors. Issue 3 (18th October 2017)

• Record Type: Journal Article
• Authors: Faruqi, Salman; Tseng, Chia-Lin; Whyne, Cari; Alghamdi, Majed; Wilson, Jefferson; Myrehaug, Sten; Soliman, Hany; Lee, Young; Maralani, Pejman; Yang, Victor; Fisher, Charles; Sahgal, Arjun
• Is Part Of: Neurosurgery. Volume 83:Issue 3(2018)
• Page Start: 314
• Page End: 322
• Publication Date: 2017-10-18
• Subjects: Spine SBRT -- Spine radiosurgery -- VCF -- Vertebral compression fracture -- SINS; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyx493
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: BACKGROUND: Vertebral compression fracture (VCF) is a challenging and not infrequent complication observed following spine stereotactic body radiation therapy (SBRT). OBJECTIVE: To summarize the data from the multiple studies that have been published, addressing the risk and predictive factors for VCF post-SBRT. METHODS: A systematic literature review was conducted. Studies were selected if they specifically addressed risk factors for post-SBRT VCF in their analyses. RESULTS: A total of 11 studies were identified, reporting both the risk of VCF post-SBRT and an analysis of risk factors based on univariate and multivariate analysis. A total of 2911 spinal segments were treated with a crude VCF rate of 13.9%. The most frequently identified risk factors on multivariate analysis were: lytic disease (hazard ratio [HR] range, 2.76-12.2), baseline VCF prior to SBRT (HR range, 1.69-9.25), higher dose per fraction SBRT (HR range, 5.03-6.82), spinal deformity (HR range, 2.99-11.1), older age (HR range, 2.15-5.67), and more than 40% to 50% of vertebral body involved by tumor (HR range, 3.9-4.46). In the 9 studies that specifically reported on the use of post-SBRT surgical procedures, 37% of VCF had undergone an intervention (range, 11%-60%). CONCLUSION: VCF is an important adverse effect following SBRT. Risk factors have been identified to guide the selection of high-risk patients. Evidence-based algorithms with respect to patient selection and intervention are needed.