Susceptibility of HLA-E*01:03 Allele Carriers to Develop Cytomegalovirus Replication After Living-Donor Kidney Transplantation. (8th December 2017)

• Record Type: Journal Article
• Authors: Guberina, Hana; da Silva Nardi, Fabiola; Michita, Rafael Tomoya; Dolff, Sebastian; Bienholz, Anja; Heinemann, Falko M; Wilde, Benjamin; Trilling, Mirko; Horn, Peter A; Kribben, Andreas; Witzke, Oliver; Rebmann, Vera
• Is Part Of: Journal of infectious diseases. Volume 217:Number 12(2018)
• Page Start: 1918
• Page End: 1922
• Publication Date: 2017-12-08
• Subjects: Cytomegalovirus -- HLA-E -- kidney tran sp lan ta tion; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jix638
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract : Cytomegalovirus (CMA) causes serious complications after transplantation. Genetic biomarkers are required for an improved individualized CMV-associated risk management. This study introduces HLA-E*01:03 allele carrier status, independent of CMV high-risk status, in transplant recipients as a prognostic factor for CMV infection after transplantation. Abstract: Cytomegalovirus (CMV) causes serious complications among solid organ transplant recipients. We report the positive correlation between the presence of the HLA-E*01:03 allele in living-donor kidney recipients and CMV reactivation during the first year after transplantation. Thus, HLA-E genotyping may help identify CMV replication–prone patients who require individualized patient-based CMV management.