Features of Dengue and Chikungunya Infections of Colombian Children under 24 Months of Age Admitted to the Emergency Department. (21st April 2017)

• Record Type: Journal Article
• Authors: Paternina-Caicedo, Angel; De la Hoz-Restrepo, Fernando; Díaz-Quijano, Fredi; Caicedo-Torres, William; Auxiliadora Badillo-Viloria, María; Bula-Anichiarico, Doris; Alvis-Guzmán, Nelson; Mattar, Salim; Constenla, Dagna; Pinzón-Redondo, Hernando
• Is Part Of: Journal of tropical pediatrics. Volume 64:Number 1(2018:Feb.)
• Page Start: 31
• Page End: 37
• Publication Date: 2017-04-21
• Subjects: dengue -- chikungunya -- severe dengue -- complications -- children; Pediatrics -- Periodicals; Tropical medicine -- Periodicals; Pediatrics -- Periodicals; Tropical Medicine -- Periodicals; Environmental Health -- Periodicals; Infant; Child; 618.929883
• DOI: 10.1093/tropej/fmx024
• Languages: English
• ISSNs: 0142-6338

Abstract

ABSTRACT: We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014–14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency admission best characterized dengue, with a sensitivity of 67% (95% CI, 53–79) and specificity of 95% (95% CI, 82–99). The algorithm developed with classification and regression tree analysis showed a sensitivity of 93% (95% CI, 68–100) and specificity of 38% (95% CI, 9–76) to diagnose dengue. Our study provides potential differential characteristics between chikungunya and dengue in young children, especially low platelet counts.