Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations. Issue 44 (2nd October 2019)

• Record Type: Journal Article
• Authors: Fu, Jianye; Gu, Zhengying; Liu, Yang; Zhang, Jun; Song, Hao; Yang, Yannan; Yang, Yang; Noonan, Owen; Tang, Jie; Yu, Chengzhong
• Is Part Of: Chemical science. Volume 10:Issue 44(2019)
• Page Start: 10388
• Page End: 10394
• Publication Date: 2019-10-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc02961c
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Designed Janus silica nanoparticles can stimulate stronger phagocytosis and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium. Abstract : A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.