Ecological impact of isolated cognitive relapses in MS. (January 2020)

• Record Type: Journal Article
• Authors: Meli, Riccardo; Roccatagliata, Luca; Capello, Elisabetta; Bruschi, Nicolò; Uccelli, Antonio; Mancardi, Gianluigi; Inglese, Matilde; Pardini, Matteo
• Is Part Of: Multiple sclerosis. Volume 26:Number 1(2020)
• Page Start: 114
• Page End: 117
• Publication Date: 2020-01
• Subjects: Relapses -- cognition -- quality of life; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458518813722
• Languages: English
• ISSNs: 1352-4585

Abstract

Isolated cognitive relapses (ICRs) are transient deficits in cognitive performance that are the only presentation of a multiple sclerosis (MS) relapse. Here, we evaluated the impact of ICRs on cognitive difficulties in daily activities (assessed with the Multiple Sclerosis Neuropsychological Screening Questionnaire, Informant Version (MSNQ-I)) to characterize ICRs' clinical relevance. We used 2-year-long retrospective data to compare 15 relapsing-remitting MS (RRMS) patients with ICRs with 57 RRMS patients presenting an asymptomatic gadolinium enhancing lesion (and no-ICRs). ICRs were associated not only with neuropsychological performance decline but also with an increase in the daily cognitive difficulties. These findings support the ecological relevance of ICRs.