Protective Effect of Maternal Influenza Vaccination on Influenza in Their Infants: A Prospective Cohort Study. (5th December 2017)
- Record Type:
- Journal Article
- Title:
- Protective Effect of Maternal Influenza Vaccination on Influenza in Their Infants: A Prospective Cohort Study. (5th December 2017)
- Main Title:
- Protective Effect of Maternal Influenza Vaccination on Influenza in Their Infants: A Prospective Cohort Study
- Authors:
- Ohfuji, Satoko
Deguchi, Masaaki
Tachibana, Daisuke
Koyama, Masayasu
Takagi, Tetsu
Yoshioka, Takayuki
Urae, Akinori
Ito, Kazuya
Kase, Tetsuo
Maeda, Akiko
Kondo, Kyoko
Fukushima, Wakaba
Hirota, Yoshio - Abstract:
- Abstract : This prospective cohort study showed that the effectiveness of prenatal and postpartum influenza vaccination of mothers in preventing influenza among their infants was 61% and 53%, respectively. Maternal influenza vaccination during the prenatal or postpartum periods had beneficial effects in protecting infants from influenza. Abstract: Background: Infants <6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications. Methods: To examine the effectiveness of maternal influenza vaccination in preventing influenza in their infants, we conducted a prospective cohort study of 3441 infants born at participating hospitals before the 2013–2014 influenza season. At the time of recruitment, their mothers completed a questionnaire about influenza vaccination status for the 2013–2014 season. A follow-up survey was conducted after the end of the 2013–2014 season to collect information regarding influenza diagnosis and hospitalization among infants. Results: During the 2013–2014 influenza season, 71 infants (2%) had influenza diagnosed, and 13 infants (0.4%) were hospitalized with influenza. Maternal influenza vaccination (especially prenatal vaccination) decreased the odds of influenza among infants. The effectiveness of prenatal vaccination was 61% (95% confidence interval, 16%–81%), whereas that of postpartum vaccination was 53% (−28%–83%). Although maternal influenza vaccination was also associated with aAbstract : This prospective cohort study showed that the effectiveness of prenatal and postpartum influenza vaccination of mothers in preventing influenza among their infants was 61% and 53%, respectively. Maternal influenza vaccination during the prenatal or postpartum periods had beneficial effects in protecting infants from influenza. Abstract: Background: Infants <6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications. Methods: To examine the effectiveness of maternal influenza vaccination in preventing influenza in their infants, we conducted a prospective cohort study of 3441 infants born at participating hospitals before the 2013–2014 influenza season. At the time of recruitment, their mothers completed a questionnaire about influenza vaccination status for the 2013–2014 season. A follow-up survey was conducted after the end of the 2013–2014 season to collect information regarding influenza diagnosis and hospitalization among infants. Results: During the 2013–2014 influenza season, 71 infants (2%) had influenza diagnosed, and 13 infants (0.4%) were hospitalized with influenza. Maternal influenza vaccination (especially prenatal vaccination) decreased the odds of influenza among infants. The effectiveness of prenatal vaccination was 61% (95% confidence interval, 16%–81%), whereas that of postpartum vaccination was 53% (−28%–83%). Although maternal influenza vaccination was also associated with a decreased odds of influenza-related hospitalization among infants, vaccine effectiveness (73%) did not reach statistical significance, owing to the limited number of infants hospitalized because of influenza. Conclusions: The present findings indicated that pregnant women and postpartum women should receive influenza vaccination to protect their infants. … (more)
- Is Part Of:
- Journal of infectious diseases. Volume 217:Number 6(2018)
- Journal:
- Journal of infectious diseases
- Issue:
- Volume 217:Number 6(2018)
- Issue Display:
- Volume 217, Issue 6 (2018)
- Year:
- 2018
- Volume:
- 217
- Issue:
- 6
- Issue Sort Value:
- 2018-0217-0006-0000
- Page Start:
- 878
- Page End:
- 886
- Publication Date:
- 2017-12-05
- Subjects:
- Influenza -- infants -- maternal vaccination -- prospective cohort study -- vaccine effectiveness
Communicable diseases -- Periodicals
Diseases -- Causes and theories of causation -- Periodicals
Medicine -- Periodicals
Communicable Diseases -- Periodicals
Electronic journals
616.9 - Journal URLs:
- http://jid.oxfordjournals.org/content/by/year ↗
http://www.journals.uchicago.edu/JID/journal/ ↗
http://www.jstor.org/journals/00221899.html ↗
http://ukcatalogue.oup.com/ ↗ - DOI:
- 10.1093/infdis/jix629 ↗
- Languages:
- English
- ISSNs:
- 0022-1899
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
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