Magee Equation Recurrence Score Is Associated With Distal Metastatic Risk in Male Breast Carcinomas: Experience From Two Institutions. Issue 6 (4th August 2018)

• Record Type: Journal Article
• Authors: Hou, Yanjun; Moosavi, Harrison S; Wei, Lai; Parwani, Anil V; Li, Xiaoxian (Bill); Li, Zaibo
• Is Part Of: American journal of clinical pathology. Volume 150:Issue 6(2018)
• Page Start: 491
• Page End: 498
• Publication Date: 2018-08-04
• Subjects: Male breast cancer -- Magee equation -- Recurrence score; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqy078
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To conduct a clinicopathologic study of male breast carcinoma with Magee equation recurrence score (RS). Methods: Seventy-four cases of male invasive breast cancers (MBCs) were studied, including 63 hormone receptor (HR)-positive, 10 human epidermal growth factor receptor 2-positive, and one triple-negative breast cancers. Results: Among 63 HR-positive MBC patients, nine patients developed distal metastasis. Statistical analysis demonstrated distal metastasis was significantly associated with positive lymph node, high Nottingham grade, and increased Magee equation RS. All HR-positive MBCs were further stratified into two categories (low RS <18; intermediate/high RS ≥18). There was a significantly increased risk for distal metastasis in MBCs with intermediate/high Magee equation RS, but no increased risk for lymph node metastasis. Conclusions: Our data suggest Magee equation RS may be useful to predict distal metastatic risk in MBC patients.