Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate–carbohydrate interactions. (3rd April 2018)

• Record Type: Journal Article
• Authors: Sletmoen, Marit; Gerken, Thomas A; Stokke, Bjørn T; Burchell, Joy; Brewer, C Fred
• Is Part Of: Glycobiology. Volume 28:Number 7(2018)
• Page Start: 437
• Page End: 442
• Publication Date: 2018-04-03
• Subjects: carbohydrate tumor antigens -- carbohydrate–carbohydrate interactions -- mechanism of action -- Neu5Gc-GM3 -- optical tweezers -- Tn and STn cancer antigens; Glycoproteins -- Periodicals; Glycolipids -- Periodicals; Glycoconjugates -- Periodicals; 572.567
• DOI: 10.1093/glycob/cwy032
• Languages: English
• ISSNs: 0959-6658

Abstract

Abstract: The mucin-type O -glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2, 6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate–carbohydrate interactions, CCIs) of Tn (Tn–Tn) and STn (STn–STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.