T-Cell Large Granular Lymphocytic Leukemia and Coexisting B-Cell Lymphomas: A Study From the Bone Marrow Pathology Group. Issue 2 (20th January 2018)

• Record Type: Journal Article
• Authors: Goyal, Tanu; Thakral, Beenu; Wang, Sa A; Bueso-Ramos, Carlos E; Shi, Min; Jevremovic, Dragan; Morice, William G; Zhang, Qian-Yun; George, Tracy I; Foucar, Kathryn K; Bhattacharyya, Siddharth; Bagg, Adam; Rogers, Heesun J; Bodo, Juraj; Durkin, Lisa; Hsi, Eric D
• Is Part Of: American journal of clinical pathology. Volume 149:Issue 2(2018)
• Page Start: 164
• Page End: 171
• Publication Date: 2018-01-20
• Subjects: T-LGL leukemia -- B-cell lymphoma -- Diffuse large B-cell lymphoma; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqx146
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).