PATIENT-SPECIFIC DOSIMETRY FOR PEDIATRIC IMAGING OF 99mTc-DIMERCAPTOSUCCINIC ACID WITH GATE MONTE CARLO CODE. Issue 2 (5th August 2017)

• Record Type: Journal Article
• Authors: Bagheri, Mahmoud; Parach, Ali Asghar; Razavi-Ratki, Seid Kazem; Nafisi-Moghadam, Reza; Jelodari, Mohammad Ali
• Is Part Of: Radiation protection dosimetry. Volume 178:Issue 2(2018)
• Page Start: 213
• Page End: 222
• Publication Date: 2017-08-05
• Subjects: Radiation dosimetry -- Periodicals; Radiation -- Safety measures -- Periodicals; 363.1799
• DOI: 10.1093/rpd/ncx101
• Languages: English
• ISSNs: 0144-8420

Abstract

Abstract: In this study, radiation absorbed dose of 99m Tc-dimercaptosuccinic acid (DMSA) in critical organs was calculated using Monte Carlo simulation. Ten child patients with genitourinary abnormalities were imaged using a series of planar, SPECT and MRI, after injection with 99m Tc-DMSA. Patient-specific organ segmentation was performed on MRI and used as input in GATE. Organs with substantial uptake included kidneys, bladder and liver. The mean organ absorbed dose coefficients (mGy/MBq) were 0.063, 0.058, 0.018, 0.016, 0.013 and 0.010 for the right kidney, left kidney, bones, urinary bladder wall, liver and gonads, respectively. The absorbed dose coefficients in the remainder of the body was 0.012 mGy/MBq. The authors implemented an image-based Monte Carlo method for patient-specific 3D absorbed dose calculation. This study also demonstrates the possibility to obtain patient-specific attenuation map from MRI to be used for the simulations of radiation transport and energy deposition in phantom using Monte Carlo methods.