The risk profile of rhegmatogenous retinal detachment before and after using a fluoroquinolone: a 12 year nationwide self-controlled case series study. (27th August 2018)

• Record Type: Journal Article
• Authors: Shin, Ju-Young; Jeong, Sohyun; Jeon, Ha-Lim; Byun, Seongjun; Park, Kyu Hyung; Jeong, Han Eol; Park, Sang Jun
• Is Part Of: Journal of antimicrobial chemotherapy. Volume 73:Number 12(2018)
• Page Start: 3442
• Page End: 3453
• Publication Date: 2018-08-27
• Subjects: Anti-infective agents -- Periodicals; Chemotherapy -- Periodicals; 615.58
• DOI: 10.1093/jac/dky336
• Languages: English
• ISSNs: 0305-7453

Abstract

Abstract: Objectives: To determine whether or not fluoroquinolone use increases the incidence of retinal detachment. Design: Self-controlled case series analysis. Participants: Participants were identified using the South Korean National Health Insurance Database between 1 January 2004 and 31 December 2015. A total of 15 134 patients who experienced rhegmatogenous retinal detachment (RRD) with at least one prescription of a fluoroquinolone were included. Methods: Incidence rate ratios (IRRs) and their 95% CIs were calculated using conditional Poisson regression. The main outcome measure was a recorded diagnosis of RRD (ICD-10: H33.0) with a claim for the surgical code for RRD. Results: We found an increased risk of retinal detachment in the first 1–30 days following the initiation of fluoroquinolone therapy (IRR 1.85; 95% CI 1.71–1.95), which rose for the 31–60 days period (IRR 2.05; 95% CI 1.43–2.95) but remained constant after more than 60 days (IRR 1.25; 95% CI 0.75–2.10). However, the elevated risk was also found in the 1–30 day period prior to the initiation of fluoroquinolone therapy (IRR 1.58; 95% CI 1.49–1.68) and also 31–60 days before medication use (IRR 1.11; 95% CI 1.03–1.19). Conclusions: Our case-based study indicated that the risk after fluoroquinolone exposure doubled; however, the risk profile before and after fluoroquinolone use means that the association between fluoroquinolone use and retinal detachment might not be a causal relationship.