Perinatal exposure to bisphenol A (BPA) impairs neuroendocrine mechanisms regulating food intake and kisspetin system in adult male rats. Evidences of metabolic disruptor hypothesis. (1st January 2020)

• Record Type: Journal Article
• Authors: Stoker, Cora; Andreoli, M. Florencia; Kass, Laura; Bosquiazzo, Verónica L.; Rossetti, M. Florencia; Canesini, G.; Luque, Enrique H.; Ramos, Jorge G.
• Is Part Of: Molecular and cellular endocrinology. Volume 499(2019)
• Publication Date: 2020-01-01
• Subjects: Bpa -- Obesogen -- Food intake -- Neuropeptides -- Kisspeptin -- Diabetes; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2019.110614
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Bisphenol A (BPA) is a compound used in the polymerization of plastic polycarbonates. It is an endocrine disruptor and it has been postulated to be an obesogen. Our objective was to determine the influence of perinatal exposure to BPA on body weight, hormone levels, metabolic parameters and hypothalamic signals that regulate food intake and kisspeptin system in adult male rats. Male rats were exposed to 50 μg/kg/day of BPA or vehicle from day 9 of gestation to weaning in the drinking water. Since weaning, they were fed with control or high fat diet for 20 weeks. Perinatal exposure to BPA impaired glucose homeostasis, induced obesity and increased food intake in adult male rats altering hypothalamic signals, partially mimicking and/or producing an exacerbation of the effects of feeding fat diet. We also observed an increase in kisspeptin expression by BPA exposure. Evidences shown in this work support the metabolic disruptor hypothesis for BPA. Highlights: Perinatal exposure to BPA increased body weight, adipose tissue and energy intake. Perinatal exposure to BPA exacerbates some effects of feeding fat diet in adult life. Increased intake is associated with changes in neuropeptides and hormonal receptors. BPA act as a metabolic disruptor since it modifies glucose homeostasis and hormones. Kisspeptin expression is enhanced in adult male rats perinatally exposed to BPA.