Metabolic influence on the differentiation of suppressive myeloid cells in cancer. (2nd July 2018)

• Record Type: Journal Article
• Authors: Porta, Chiara; Marino, Arianna; Consonni, Francesca Maria; Bleve, Augusto; Mola, Silvia; Storto, Mariangela; Riboldi, Elena; Sica, Antonio
• Is Part Of: Carcinogenesis. Volume 39:Number 9(2018)
• Page Start: 1095
• Page End: 1104
• Publication Date: 2018-07-02
• Subjects: Carcinogenesis -- Periodicals; Cancer -- Genetic aspects -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Periodicals; 616.994071
• DOI: 10.1093/carcin/bgy088
• Languages: English
• ISSNs: 0143-3334

Abstract

Abstract : Growing evidence indicates that metabolism of tumor associated myeloid cells contributes to the differentiation of their suppressive phenotype and therefore to cancer immune evasion. Abstract: New evidences indicate that the metabolic instruction of immunity (immune metabolism) results from the integration of cell metabolism and whole-body metabolism, which are both influenced by nutrition, microbiome metabolites and disease-driven metabolism (e.g. cancer metabolism). Cancer metabolism influences the immunological homeostasis and promotes immune alterations that support disease progression, hence influencing the clinical outcome. Cancer cells display increased glucose uptake and fermentation of glucose to lactate, even in the presence of completely functioning mitochondria. A major side effect of this event is immunosuppression, characterized by limited immunogenicity of cancer cells and restriction of the therapeutic efficacy of anticancer immunotherapy. Here, we discuss how the metabolism of myeloid cells associated with cancer contributes to the differentiation of their suppressive phenotype and therefore to cancer immune evasion.