Micro-Hotspots of Risk in Urban Cholera Epidemics. (11th May 2018)

• Record Type: Journal Article
• Authors: Azman, Andrew S; Luquero, Francisco J; Salje, Henrik; Mbaïbardoum, Nathan Naibei; Adalbert, Ngandwe; Ali, Mohammad; Bertuzzo, Enrico; Finger, Flavio; Toure, Brahima; Massing, Louis Albert; Ramazani, Romain; Saga, Bansaga; Allan, Maya; Olson, David; Leglise, Jerome; Porten, Klaudia; Lessler, Justin
• Is Part Of: Journal of infectious diseases. Volume 218:Number 7(2018)
• Page Start: 1164
• Page End: 1168
• Publication Date: 2018-05-11
• Subjects: cholera -- clustering -- ring vaccination -- targeted interventions -- vibrio cholerae; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiy283
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and Democratic Republic of the Congo, we estimate the extent of spatiotemporal zones of increased cholera risk around cases. In both cities, we found zones of increased risk of at least 200 meters during the 5 days immediately after case presentation to a clinic. Risk was highest for those living closest to cases and diminished in time and space similarly across settings. These results provide a rational basis for rapidly delivering targeting interventions.