Association between layer-specific global longitudinal strain and adverse outcomes following acute coronary syndrome. (30th March 2018)

• Record Type: Journal Article
• Authors: Skaarup, Kristoffer Grundtvig; Iversen, Allan; Jørgensen, Peter Godsk; Olsen, Flemming Javier; Grove, Gabriela Llado; Jensen, Jan Skov; Biering-Sørensen, Tor
• Is Part Of: European heart journal. Volume 19:Number 12(2018)
• Page Start: 1334
• Page End: 1342
• Publication Date: 2018-03-30
• Subjects: acute coronary syndrome -- 2D-speckle tracking echocardiography -- heart failure -- cardiovascular death -- layer-specific 2D-speckle tracking; Cardiovascular system -- Imaging -- Periodicals; Heart -- Imaging -- Periodicals; 616.10754
• DOI: 10.1093/ehjci/jey004
• Languages: English
• ISSNs: 2047-2404

Abstract

Abstract: Aims: To investigate the prognostic value of layer-specific global longitudinal strain (GLS) in predicting heart failure (HF) and cardiovascular death (CD) following acute coronary syndrome (ACS). Methods and results: In this retrospective study, 465 ACS patients underwent transthoracic echocardiography following percutaneous coronary intervention (PCI). The primary endpoint was the composite of HF and/or CD with a median follow-up time of 4.6 (0.2–6.3) years. During follow-up 199 patients (42.7%) suffered HF and/or CD (176 developed HF and 38 suffered CD). Absolute endomyocardial global longitudinal strain (GLSendo) (12% vs. 17%, P < 0.001), GLS (11% vs. 14%, P < 0.001), and epimyocardial global longitudinal strain (GLSepi) (9% vs. 13%, P < 0.001) were all reduced in patients with an adverse outcome. In multivariable Cox regressions, which included clinical baseline characteristics and conventional echocardiographic measurements, GLS obtained from all layers remained independently associated with the composite outcome; GLSendo [hazard ratio: 1.19 (1.10–1.28), P < 0.001, per 1% decrease], GLS [hazard ratio 1.24 (1.14–1.35), P < 0.001, per 1% decrease], and GLSepi [hazard ratio 1.26 (1.15–1.39), P < 0.001, per 1% decrease]. No other echocardiographic measures remained independently associated with the composite outcome in these models. Finally, GLS and GLSepi provided incremental prognostic information on the risk of developing the composite endpoint, when added to all other clinical and echocardiographic measures [adding GLS (c-statistics: 0.76 vs. 0.74, P = 0.048) or adding GLSepi (c-statistics: 0.76 vs. 0.74, P = 0.039)]. Conclusion: In ACS patients, layer-specific strain provides independent prognostic information regarding risk of developing HF and/or CD. Furthermore, only GLS and GLSepi provided incremental prognostic information when added to all other significant predictors.