Viral Load in the Natural History of Human Papillomavirus Infection Among Men in Rural China: A Population-based Prospective Study. (28th June 2018)

• Record Type: Journal Article
• Authors: Liu, Mengfei; Liu, Fangfang; Pan, Yaqi; He, Zhonghu; Guo, Chuanhai; Zhang, Chanyuan; Li, Xiang; Hang, Dong; Wang, Qiyan; Liu, Ying; Li, Jingjing; Liu, Zhen; Cai, Hong; Ke, Yang
• Is Part Of: Clinical infectious diseases. Volume 67:Number 12(2018)
• Page Start: 1861
• Page End: 1867
• Publication Date: 2018-06-28
• Subjects: human papillomavirus -- viral load -- natural history -- men -- China; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciy376
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract : Men with multiple lifetime sex partners are more likely to have higher levels of high-risk human papillomavirus (HR-HPV) load. Higher HR-HPV load predicts persistence of HR-HPV in men from rural China. Abstract: Background: High-risk human papillomavirus (HR-HPV) load is predictive of HR-HPV persistence and subsequent carcinogenesis in women. However, in men, data on genital HPV load and its effect on the natural history of HPV infection are limited. Methods: The subjects included 1532 men aged 25–65 years with up to 7 biannual visits for evaluation of genital HPV load in rural China during 2009–2013 who were positive for ≥1 of the 18 selected HPV types (including 10 HR-HPV types) detected by general primer-mediated polymerase chain reaction (PCR) and sequencing. Type-specific HPV load was quantified with real-time PCR and dichotomized based on median values. Results: Men with multiple lifetime sex partners were more likely to have higher overall levels of HR-HPV load across visits (adjusted odds ratio, 2.42; 95% confidence interval [CI], 1.12–5.24; 2 partners vs 0–1 partner). Higher levels of HR-HPV load at the time of the first HPV diagnosis conferred an increased probability of the subject remaining type-specific HPV-positive up to 12 months and an increased probability of persistent/intermittent infection (virus detected repeatedly with or without a period of intercurrent negativity) versus transient infections (single-time positive). Higher overall HR-HPV levels were predictive of reduced HR-HPV clearance rates (adjusted hazard ratio, 0.47; 95% CI, .27–.83). Conclusions: Having multiple lifetime sex partners is associated with increased male genital HR-HPV load. Higher HR-HPV load predicts persistence of HR-HPV in men from rural China.