Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice. (21st March 2018)

• Record Type: Journal Article
• Authors: Hitomi, Kaori; Tahara-Hanaoka, Satoko; Miki, Haruka; Iwata, Kanako; Shibayama, Shiro; Kubo, Masato; Shibuya, Akira
• Is Part Of: International immunology. Volume 30:Number 9(2018)
• Page Start: 429
• Page End: 434
• Publication Date: 2018-03-21
• Subjects: allergic asthma -- immunoglobulin-like receptor -- ITIM -- FcεRI; Immunology -- Periodicals; 616.079
• DOI: 10.1093/intimm/dxy025
• Languages: English
• ISSNs: 0953-8178

Abstract

Abstract: Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient Kit W-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR.