Cumulative Antiretroviral Exposure Measured in Hair Is Not Associated With Measures of HIV Persistence or Inflammation Among Individuals on Suppressive ART. (26th February 2018)

• Record Type: Journal Article
• Authors: Gandhi, Monica; Gandhi, Rajesh T; Stefanescu, Andrei; Bosch, Ronald J; Cyktor, Joshua C; Horng, Howard; Louie, Alexander; Phung, Nhi; Eron, Joseph J; Hogg, Evelyn; Macatangay, Bernard J C; Hensel, Christopher; Fletcher, Courtney V; Mellors, John W; McMahon, Deborah K
• Is Part Of: Journal of infectious diseases. Volume 218:Number 2(2018)
• Page Start: 234
• Page End: 238
• Publication Date: 2018-02-26
• Subjects: HIV -- antiretroviral therapy -- hair concentrations -- measures of HIV persistence -- HIV-related inflammation; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiy011
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract : We showed no significant correlation between antiretroviral hair concentrations and measures of HIV persistence or soluble markers of inflammation, suggesting that higher cumulative ARV exposure may not impact the HIV reservoir or inflammation. Further study in real-world populations are indicated. Abstract: Data on the relationship of antiretroviral exposure to measures of human immunodeficiency virus (HIV) persistence are limited. To address this gap, multiple viral, immunologic, and pharmacologic measures were analyzed from individuals with sustained virologic suppression on therapy (median 7 years) in the AIDS Clinical Trials Group A5321 cohort. Among 110 participants on tenofovir-(TFV)-disoproxil-fumarate (TDF)/emtricitabine (FTC)-containing regimens, we found no significant correlation between hair concentrations of individual antiretrovirals (ARVs) in the regimen and measures of HIV persistence (plasma HIV-1 RNA by single copy assay, cell-associated-DNA, cell-associated RNA) or soluble markers of inflammation. These findings suggest that higher systemic ARV exposure may not impact HIV persistence or inflammation.