Mannose-capped lipoarabinomannan in Mycobacterium tuberculosis pathogenesis. Issue 4 (24th March 2018)

• Record Type: Journal Article
• Authors: Turner, Joanne; Torrelles, Jordi B
• Is Part Of: Pathogens and disease. Volume 76:Issue 4(2018)
• Publication Date: 2018-03-24
• Subjects: tuberculosis -- Mycobacterium tuberculosis -- mannose-capped lipoarabinomannan -- host cell response -- biological functions; Medical microbiology -- Periodicals; Pathogenic microorganisms -- Periodicals; Communicable diseases -- Microbiology -- Periodicals; Communicable diseases -- Pathogenesis -- Periodicals; Host-parasite relationships -- Periodicals; Systems biology -- Periodicals; 616.904105
• DOI: 10.1093/femspd/fty026
• Languages: English
• ISSNs: 2049-632X

Abstract

Abstract: Mannose-capped lipoarabinomannan (ManLAM), present in all members of the Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high molecular mass amphipathic lipoglycan with a defined critical role in mycobacterial survival during infection. In particular, ManLAM is well-characterized for its importance in providing M. tuberculosis a safe portal of entry to phagocytes, regulating the intracellular trafficking network, as well as immune responses of infected host cells. These ManLAM immunological characteristics are thought to be linked to the subtle but unique and well-defined structural characteristics of this molecule, including but not limited to the degree of acylation, the length of the D-mannan and D-arabinan cores, the length of the mannose caps, as well as the presence of other acidic constituents such as succinates, lactates and/or malates, and also the presence of 5-methylthioxylosyl. The impact of all these structural features on ManLAM spatial conformation and biological functions during M. tuberculosis infection is still uncertain. In this review, we dissect the relationship between ManLAM structure and biological function addressing how this relationship determines M. tuberculosis interactions with host cells, and how it aids this exceptional pathogen during the course of infection. Abstract : Mycobacterium tuberculosis mannose-capped lipoarabinomannan: relationship between structure and biological function.