Mood Disorders and Risk of Herpes Zoster in 2 Population-Based Case-Control Studies in Denmark and the United Kingdom. Issue 5 (19th October 2017)

• Record Type: Journal Article
• Authors: Schmidt, Sigrun A J; Langan, Sinéad M; Pedersen, Henrik S; Schønheyder, Henrik C; Thomas, Sara L; Smeeth, Liam; Mansfield, Kathryn E; Sørensen, Henrik T; Forbes, Harriet J; Vestergaard, Mogens
• Is Part Of: American journal of epidemiology. Volume 187:Issue 5(2018)
• Page Start: 1019
• Page End: 1028
• Publication Date: 2017-10-19
• Subjects: adjustment disorders -- anxiety -- depression -- herpes zoster -- stress disorders; Epidemiology -- Periodicals; Public health -- Periodicals; 614.4
• DOI: 10.1093/aje/kwx338
• Languages: English
• ISSNs: 0002-9262

Abstract

Abstract: We examined the association between mood disorders and risk of herpes zoster in two case-control studies using data from nationwide Danish registries and practices in the UK Clinical Practice Research Datalink. We included incident zoster cases diagnosed in general practice (using systemic antivirals as a proxy in Denmark) or hospital during 1997–2013 in Denmark ( n = 190, 671) and during 2000–2013 in the United Kingdom ( n = 177, 361). We risk-set sampled 4 matched population controls per case. Conditional logistic regression analyses adjusting for zoster risk factors showed that the odds ratios for previous mood disorder among cases versus controls were 1.15 (99% confidence interval (CI): 1.12, 1.19; prevalence 7.1% vs. 6.0%) in Denmark and 1.12 (99% CI: 1.11, 1.14; prevalence 31.6% vs. 29.2%) in the United Kingdom. In Denmark, odds ratios were higher for anxiety (1.23; 99% CI: 1.17, 1.30) and severe stress and adjustment disorder (1.24; 99% CI: 1.18, 1.30) than for depression (1.11; 99% CI: 1.07, 1.14). In the United Kingdom, odds ratios for these conditions were similar: 1.12 (99% CI: 1.10, 1.13), 1.12 (99% CI: 1.10, 1.14), and 1.14 (99% CI: 1.10, 1.19) for depression, anxiety, and severe stress and adjustment disorder, respectively. In conclusion, mood disorders were associated with an increased risk of zoster.