Trends in Bone Marrow Sampling and Core Biopsy Specimen Adequacy in the United States and Canada: A Multicenter Study. Issue 5 (20th July 2018)

• Record Type: Journal Article
• Authors: Merzianu, Mihai; Groman, Adrienne; Hutson, Alan; Cotta, Claudiu; Brynes, Russell K; Orazi, Attilio; Reddy, Vishnu; Teruya-Feldstein, Julie; Amre, Ramila; Balasubramanian, Manjula; Brandao, Guilherme; Cherian, Sindhu; Courville, Elizabeth; Czuchlewski, David; Fan, Guang; Grier, David; Hoehn, Daniela; Inamdar, Kedar V; Juskevicius, Ridas; Kaur, Prabhjot; Lazarchick, John; Lewis, Michael R; Miles, Rodney R; Myers, Jerome B; Nasr, Michel R; Qureishi, Hina N; Olteanu, Horatiu; Robu, Valentin G; Salaru, Gratian; Vajpayee, Neerja; Vos, Jeffrey; Zhang, Ling; Zhang, Shanxiang; Aye, Le; Brega, Elisa; Coad, James E; Grantham, John; Ivelja, Sinisa; McKenna, Robert; Sultan, Kieran; Wilding, Gregory; Hutchison, Robert; Peterson, LoAnn; Cheney, Richard T;
• Is Part Of: American journal of clinical pathology. Volume 150:Issue 5(2018)
• Page Start: 393
• Page End: 405
• Publication Date: 2018-07-20
• Subjects: Bone marrow biopsy -- Bone marrow biopsy indications -- Core biopsy length -- Bone marrow adequacy -- Bone marrow quality; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqy066
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To assess bone marrow (BM) sampling in academic medical centers. Methods: Data from 6, 374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. Results: BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. Conclusions: CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable.