Value of HPV 16/18 Genotyping and p16/Ki-67 Dual Staining to Predict Progression to HSIL/CIN2+ in Negative Cytologies From a Colposcopy Referral Population. Issue 5 (20th July 2018)

• Record Type: Journal Article
• Authors: Rodríguez-Trujillo, Adriano; Martí, Cristina; Angeles, Martina Aida; Sierra, Adriana; Esteve, Roser; Saco, Adela; Barnadas, Esther; Marimón, Lorena; Nicolás, Inmaculada; Torné, Aureli; Ordi, Jaume; del Pino, Marta
• Is Part Of: American journal of clinical pathology. Volume 150:Issue 5(2018)
• Page Start: 432
• Page End: 440
• Publication Date: 2018-07-20
• Subjects: Cervical cancer -- HPV genotyping -- p16/Ki-67 dual staining -- Colposcopy -- Random biopsy -- HSIL/CIN2+; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqy071
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To assess the prognostic value of human papillomavirus (HPV) 16/18 genotyping and p16/Ki-67 dual staining cytology in high-risk HPV (hrHPV)–positive women with no lesion or minor abnormalities. Methods: We evaluated progression to high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grades 2 to 3 or cervical cancer (HSIL/CIN2+), persistence/regression of hrHPV infection in women referred to colposcopy showing hrHPV infection, histology diagnosis different from HSIL/CIN2+, and negative cytology. HPV 16/18 genotyping and dual staining were performed in liquid-based cytologic specimens obtained on the first visit. Results: Progression was observed in 16 (8.0%) of 200 women. Those with HPV 16/18 infection had an increased risk of progression compared with women infected by other hrHPV types, and they also showed more persistence. However, no association was observed between progression or persistence and the result of the dual staining. Conclusions: HPV 16/18–positive women with no lesions or minor abnormalities are at high risk of progression to HSIL/CIN2+ and hrHPV persistence.