Multivalent glycan arrays. (12th July 2019)

• Record Type: Journal Article
• Authors: Mende, Marco; Bordoni, Vittorio; Tsouka, Alexandra; Loeffler, Felix F.; Delbianco, Martina; Seeberger, Peter H.
• Is Part Of: Faraday discussions. Volume 219(2019)
• Page Start: 9
• Page End: 32
• Publication Date: 2019-07-12
• Subjects: Chemistry -- Periodicals; Metallurgy -- Periodicals; Electrochemistry -- Periodicals; 540
• DOI: 10.1039/c9fd00080a
• Languages: English
• ISSNs: 1359-6640

Abstract

Abstract : In this introductory lecture we discuss the state-of-the-art glycan microarray technology, with emphasis on novel approaches to immobilize collections of glycans in a defined, multivalent manner. Abstract : Glycan microarrays have become a powerful technology to study biological processes, such as cell–cell interaction, inflammation, and infections. Yet, several challenges, especially in multivalent display, remain. In this introductory lecture we discuss the state-of-the-art glycan microarray technology, with emphasis on novel approaches to access collections of pure glycans and their immobilization on surfaces. Future directions to mimic the natural glycan presentation on an array format, as well as in situ generation of combinatorial glycan collections, are discussed.