A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging. Issue 11 (2nd October 2019)

• Record Type: Journal Article
• Authors: Elamathi, C.; Butcher, R. J.; Mohankumar, A.; Sundararaj, P.; Madankumar, A.; Kalaivani, P.; Prabhakaran, R.
• Is Part Of: Inorganic chemistry frontiers. Volume 6:Issue 11(2019)
• Page Start: 3237
• Page End: 3244
• Publication Date: 2019-10-02
• Subjects: Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c9qi00992b
• Languages: English
• ISSNs: 2052-1553

Abstract

Abstract : A highly sensitive and selective "on–off–on" chemosensor for aspartic acid in aqueous solution was established. In vitro live cell imaging against MCF 7 cells and in vivo imaging using C. elegans were successfully demonstrated. Abstract : A naturally occurring nitrogen heterocycle-based Schiff base sensor 8-methyl-2-oxo-1, 2-dihydroquinoline-3-carboxaldehyde-4 N -phenylsemicarbazone (8MPS ) was synthesized; a highly sensitive and selective "on–off–on" chemosensor for aspartic acid in aqueous solution was established. In vitro live cell imaging of 8MPS, 8MPSC and 8MPSCA against human breast cancer cells and in vivo imaging using C. elegans as a model have been successfully demonstrated. The sensing probe (8MPS ) showed enhanced green fluorescence.