The Differential Effects of Human Immunodeficiency Virus and Hepatitis C Virus on Bone Microarchitecture and Fracture Risk. (14th November 2017)

• Record Type: Journal Article
• Authors: Bedimo, Roger J; Adams-Huet, Beverley; Poindexter, John; Brown, Geri; Farukhi, Irfan; Castanon, Rosinda; Turner, Diana; Moore, Teresa; Tebas, Pablo; Maalouf, Naim M
• Is Part Of: Clinical infectious diseases. Volume 66:Number 9(2018)
• Page Start: 1442
• Page End: 1447
• Publication Date: 2017-11-14
• Subjects: HIV -- HCV -- bone mineral density -- trabecular bone score -- fracture risk; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/cix1011
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract : The mechanism(s) underlying the increased fracture risk associated with HIV and hepatitis C virus (HCV) infection are incompletely understood. We hereby show for the first time that HCV, but not HIV, is associated with bone microarchitectural changes predictive of increased fracture risk. Abstract: Background: Human immunodeficiency virus (HIV)/hepatitis C virus (HCV)–coinfected individuals have a significantly greater osteoporotic fracture risk than HIV-monoinfected persons, despite the fact that HIV/HCV coinfection has not been associated with lower bone mineral density (BMD) than HIV or HCV alone. To evaluate if changes in bone microarchitecture, measured by trabecular bone score (TBS), could explain these differences, we performed a prospective, cross-sectional cohort study of virologically suppressed HIV-infected subjects, untreated HCV-infected subjects, HIV/HCV-coinfected subjects, and uninfected controls. Methods: We enrolled 532 male subjects: 57 HIV/HCV coinfected, 174 HIV infected, 123 HCV infected, and 178 controls. We conducted analysis of covariance comparing BMD and TBS between groups, controlling for age, race, body mass index, and smoking. We used linear regression to evaluate predictors of BMD and TBS and evaluated the effects of severity of HCV infection and tenofovir disoproxil fumarate use. Results: Despite both infections being associated with decreased BMD, only HCV, but not HIV, was associated with lower TBS score. Also, HIV/HCV-coinfected subjects had lower TBS scores than HIV-monoinfected, HCV-monoinfected, and uninfected subjects. Neither the use of TDF or HCV viremia nor the severity of HCV liver disease was associated with lower TBS. Conclusions: HCV infection is associated with microarchitectural changes at the lumbar spine as assessed by the low TBS score, suggesting that microstructural abnormalities underlie some of the higher fracture risk in HCV infection. TBS might improve fracture risk prediction in HCV infection.